The leukemia-associated cell surface antigen p 24 is found on normal platelets as well as on Bernard Soulier syndrome and thrombasthenia type I platelets. AI& IgG (a monoclonal antibody against p 24) induces the aggregation of platelets from normal donors but not from thrombasthenia. In contrast, AI& Fab inhibits platelet aggregation induced by collagen, ADP, thrombin, ionophore A 23187 and ALBe IgG. The results suggest that AL&, interferes with a mechanism common to all aggregation pathways; the possible mechanisms are discussed.
Platelet aggregation Monoclonal antibody Leukemia Calcium
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