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A triboelectric nanogenerator (TENG) is a new energy harvester that converts small scale mechanical motions into electrical energy by a combination of triboelectrification and electrostatic induction through the periodic contact-separation...

Abstract-A multidisciplinary project was developed, combining the synthesis of a series of b-nitrostyrene derivatives and the determination of their physicochemical parameters (redox potentials, partition coefficients), to the evaluation of the corresponding antibacterial activity. A complete conformational analysis was also performed, in order to get relevant structural information. Subsequently, a structure-property-activity (SPAR) approach was applied, through linear regression analysis, aiming at obtaining a putative correlation between the physicochemical parameters of the compounds investigated and their antibacterial activity (both against standard strains and clinical isolates). The b-nitrostyrene compounds displayed a lower activity towards all the tested bacteria relative to the b-methyl-b-nitrostyrene analogues. This was observed particularly for the 3-hydroxy-4-methoxy-b-methyl-bnitrostyrene (IVb) against the Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium). The SPAR results revealed the existence of a clear correlation between the redox potentials and the antibacterial activity of the series of b-nitrostyrene derivatives under study.

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