A case of intravascular hemolytic transfusion reaction without detectable antibodies occurring in a
55-year-old male is reported. Specificity for the C antigen in the Rh system was demonstrated by technetium-99m red
cell survival studies. A cell-mediated mechanism of hemolysis was suspected and investigated. Previously reported
cases are reviewed and discussed. The entity of intravascular hemolytic transfusion reaction associated with minimal
symptoms and no detectable antibodies deserves further investigation.
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