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In the present study Nano Calcium-Aluminium mixed oxide material (NCAMO) was synthesized by solution combustion method in 1:1, 1:2, 4:1, 3:2 molar ratios of Calcium and Aluminum nitrates as oxidizers and urea as fuel for an efficient adsorption of fluoride from drinking water.Molar composition of 1:1 ratio was found to exhibit better adsorption properties and the same Downloaded by [University of Birmingham] at 02:47 23 March 2015 A c c e p t e d M a n u s c r i p t 2 was characterized by XRD, FESEM, and FTIR. The optimized conditions for maximum adsorption capacity were achieved at pH4 with contact time of 4 hours by adding 1g/L of NCAMO to initial fluoride concentration of 8mg/L. The sorption of fluoride on NCAMO followed Langmuir isotherm model strongly suggested monolayer adsorption. The calculated equilibrium adsorption capacity 23.7 mg/g of NCAMO strongly suggests the dominance of monolayer adsorption process. The adsorption kinetics was well described by pseudo-second order equation confirming chemisorption.

Objective: The current study was projected to prepare a losartan potassium gastroretentive drug delivery system (GRDDS) of floating tablets was planned to enhance the gastric residence time, thus prolong the drug release.Methods: Effervescent floating matrix tablets of losartan potassium were prepared by direct compression technique using polymers like HPMC k4m, guar gum, and gum karaya, with lubricants magnesium stearate and talc. In the present study, sodium bicarbonate was incorporated as a gas generating agent. Total nine formulations were designed and evaluated for pre-compression parameters known as the angle of repose, bulk density, tapped density, Hausner’s ratio, compressibility index, and post-compression parameters are uniformity of weight, hardness, and drug content percentage, variability, in vitro buoyancy, dissolution studies, and Fourier transform infrared spectroscopy (FTIR).Results: An in vitro dissolution study was carried out by using buffer pH 1.2. From in vitro dissolution studies, it has been found that an increase in polymer concentration diminishes the drug release profile. The in vitro drug release percentage from F4-F9 formulations ranged from 60.28%-98.66% at the closing of 12 h and buoyancy found over 12 h.Conclusion: The in vitro drug release from F1-F3 and F7-F9 followed zero-order, F4 followed Higuchi order, F5 and F6 followed Hixon-Crowell release kinetics. The drug release mechanism was set up to be F1-F8 non-Fickian (anomalous behavior) and F9 having Fickian diffusion type.

Ceria-incorporated trititanate nanotube composite (CTNC) was synthesized via a simple two-step wet chemical route for efficient fluoride removal not only from synthetic water but also from groundwater. The synthesized nanomaterial was systematically characterized for its physical and chemical properties. CTNC was shown to be highly porous with a surface area of 267 m2/g. The high surface area exposed majority of its adsorption sites, that is, surface hydroxyl groups, for fluoride removal. The plausible adsorption mechanism deduced based on FTIR and XPS data showed that ion exchange between the surface hydroxyl groups and the fluoride ions in water played a vital role in defluoridation by CTNC. A novel approach was used to quantify the adsorption sites with the use of BET and thermogravimetric analysis. TEM images confirmed the morphology of CTNC to be nanotubes decorated with ceria particles. The analysis of treated water samples for the metal ion content was carried out by an ICP-MS technique. CTNC exhibited characteristics of an ideal adsorbent such as high adsorption capacity, faster kinetics, pH independent adsorption, good regeneration, and negligible leaching of metal ions into the effluent. These attractive characteristics enabled the applicability of CTNC for real-time use.

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