SummaryTo compare the compliance with and tolerance of mefloquine ( M Q ) and chloroquine + proguanil (CQ-PRO) chemoprophylaxis, we conducted a study using a self-reported questionnaire i n 2 groups of native French adult visitors to Senegal or Kenya. C Q (TOO m g daily) + P R O (200 mg daily) prophylaxis was prescribed f o r all patients travelling to Senegal and for those going to Kenya when M Q was contraindicated; M Q (250 mg weekly) was prescribed for the other subjects. There were n o significant differences in age, sex, exposition and measures of protection against mosquito bites, concomitant drug use o r mean duration of chemoprophylaxis between the z groups, and compliance during travel was excellent in both. Chcmoprophylaxis w:is 11101-c frequently interrupted prematurely in the M Q group. T h e rates of overall sidc-effects attributed to malaria cheinoprophylaxis were 16% for M Q against 12% for CQ-PRO (not signihcant).However, nonserious neuropsychiatric adverse events are more frequent with MQ: I 1.5 "/ o compared to Z"/O with CQ-PRO. M Q should be used with caution.

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