Because of difficulty in reinducing comparable degrees of hypoprothrombinemia in the same patient with identical doses of this anticoagulant, it is difficult to determine the effectiveness of the antagonists. Use of menadione sodium bisulfite seems to accelerate slightly the return to normal, particularly if the prothrombin time is prolonged beyond the upper limit of the therapeutic range. It is questionable whether vitamin Kt given orally is more effective, but if given intravenously it may be slightly more effective as an antagonist for ethyl biscoumacetate.Experiments on animals have indicated that when extreme degrees of hypoprothrombinemia were induced and maintained with anticoagulant No. 63, less bleeding was encountered than when similar degrees of hypoprothrombinemia were induced and maintained with bishydroxycoumarin. With adequately controlled anticoagulant therapy comparable situations should not be

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