Conclusions: the achieved results point to the specific therapeutical response to different groups of antidepressive drugs in adolescence, which may be explained by psychobiological and age factors, and especially to the incomplete morphofunctional brain maturation, and with the hormone and immunological disbalance in puberty. This confirms the necessity to single out adolescent psychopharmacotherapy into a special area and to study it on different levels. Duloxetine resulted in a significant reduction in severity of overall pain compared with placebo. Duloxetine was well tolerated and none of the duloxetine-treated patients reported any serious adverse events. These results indicate that duloxetine administered at 60 mg once daily is a safe and efficacious treatment of MDD. Moreover, these results also indicate that duloxetine may be an important treatment for MDD patients with physical symptoms, including pain.
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