The distribution ofMycoplasma pneumoniae infection in the respiratory tract and the extent of pulmonary pathology were determined by the site ofdeposition and the number of organisms administered to hamsters. Infection of the upper and lower areas of the respiratory tract occurred when organisms were introduced into both areas by small-particle aerosol (2.3 gm) or by intranasal (i.n.) instillation of a 200-,ul inoculum. In contrast, when organisms were delivered primarily to the upper respiratory tract by large-particle aerosol (8 ,um) or by i.n. instillation of a small volume of inoculum (2 or 20 uld), infection remained
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