Aims/hypothesisFTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians.MethodsAll studies published on the association between FTO-rs9939609 (or proxy [r2 > 0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes.ResultsThe FTO-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (p = 9.0 × 10−19), overweight by 1.13-fold/allele (p = 1.0 × 10−11) and type 2 diabetes by 1.15-fold/allele (p = 5.5 × 10−8). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, p = 6.6 × 10−5). The FTO-rs9939609 minor allele increased BMI by 0.26 kg/m2 per allele (p = 2.8 × 10−17), WHR by 0.003/allele (p = 1.2 × 10−6), and body fat percentage by 0.31%/allele (p = 0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12–20%) than South Asians (30–33%), the effect of FTO variation on obesity-related traits and type 2 diabetes was similar in the two populations.Conclusions/interpretationFTO is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, FTO is also associated with type 2 diabetes independently of BMI.Electronic supplementary materialThe online version of this article (doi:10.1007/s00125-011-2370-7) contains peer-reviewed but unedited supplementary material, which is available to authorised users.

Pursuing efficient and low-cost electrocatalysts is crucial for the performance of water-alkali electrolyzers toward water splitting. Earth-abundant transition-metal oxides, in spite of their alluring performances in the oxygen evolution reaction, are thought to be inactive in the hydrogen evolution reaction in alkaline media. Here, we demonstrate that pure TiO 2 single crystals, a typical transition-metal oxide, can be activated toward electrocatalytic hydrogen evolution reaction in alkaline media through engineering interfacial oxygen vacancies. Experimental and theoretical results indicate that subsurface oxygen vacancies and low-coordinated Ti ions (Ti 3+) can enhance the electrical conductivity and promote electron transfer and hydrogen desorption, which activate reduced TiO 2 single crystals in the hydrogen evolution reaction in alkaline media. This study offers a rational route for developing reduced transitionmetal oxides for low-cost and highly active hydrogen evolution reaction catalysts, to realize overall water splitting in alkaline media.

We explore the formation of single bilayer Sb(111) ultrathin film (Antimonene) on Bi2Te3 and Sb2Te3 substrates for the first time, which is theoretically predicated to be a robust trivial semiconductor but can be tuned to a 2D TI by reducing the buckling height. From angle-resolved photoemission spectroscopy measurements, the antimonene can be well grown on the two surfaces and shows clear band dispersion. The electronic structure of the antimonene shows similar character on the two surfaces, but due to the interfacial strain effect, the bands of antimonene on Bi2Te3 are flatter than on Sb2Te3, which attributes to Bi2Te3 substrate lattice constants lager than Sb2Te3. At the same time, the charge transfer effect is also observed through core level shift, which influences the band dispersion simultaneously.

Epitaxial silicene, which is one single layer of silicon atoms packed in a honeycomb structure, demonstrates a strong interaction with the substrate that dramatically affects its electronic structure. The role of electronic coupling in the chemical reactivity between the silicene and the substrate is still unclear so far, which is of great importance for functionalization of silicene layers. Here, we report the reconstructions and hybridized electronic structures of epitaxial 4 × 4 silicene on Ag(111), which are revealed by scanning tunneling microscopy and angle-resolved photoemission spectroscopy. The hybridization between Si and Ag results in a metallic surface state, which can gradually decay due to oxygen adsorption. X-ray photoemission spectroscopy confirms the decoupling of Si-Ag bonds after oxygen treatment as well as the relatively oxygen resistance of Ag(111) surface, in contrast to 4 × 4 silicene [with respect to Ag(111)]. First-principles calculations have confirmed the evolution of the electronic structure of silicene during oxidation. It has been verified experimentally and theoretically that the high chemical activity of 4 × 4 silicene is attributable to the Si pz state, while the Ag(111) substrate exhibits relatively inert chemical behavior.

Abstract2D Dirac materials supported by nonmetallic substrates are of particular interest due to their significance for the realization of the quantum spin Hall effect and their application in field‐effect transistors. Here, monolayer germanene is successfully fabricated on semiconducting germanium film with the support of a Ag(111) substrate. Its linear‐like energy–momentum dispersion and large Fermi velocity are derived from the pronounced quasiparticle interference patterns in a √3 × √3 superstructure. In addition to Dirac fermion characteristics, the theoretical simulations reveal that the energy gap opens at the Brillouin zone center of the √3 × √3 restructured germanene, which is evoked by the symmetry‐breaking perturbation potential. These results demonstrate that the germanium nanosheets with √3 × √3 germanene can be an ideal platform for fundamental research and for the realization of high‐speed and low‐energy‐consumption field‐effect transistors.

Interlayer interactions perturb the electronic structure of two-dimensional materials and lead to new physical phenomena, such as van Hove singularities and Hofstadter’s butterfly pattern. Silicene, the recently discovered two-dimensional form of silicon, is quite unique, in that silicon atoms adopt competing sp2 and sp3 hybridization states leading to a low-buckled structure promising relatively strong interlayer interaction. In multilayer silicene, the stacking order provides an important yet rarely explored degree of freedom for tuning its electronic structures through manipulating interlayer coupling. Here, we report the emergence of van Hove singularities in the multilayer silicene created by an interlayer rotation. We demonstrate that even a large-angle rotation (>20°) between stacked silicene layers can generate a Moiré pattern and van Hove singularities due to the strong interlayer coupling in multilayer silicene. Our study suggests an intriguing method for expanding the tunability of the electronic structure for electronic applications in this two-dimensional material.

Abstract. This paper investigates the single and combined impacts of El Niño-Southern Oscillation (ENSO) and the Pacific Decadal Oscillation (PDO) on precipitation and streamflow in China over the last century. Results indicate that the precipitation and streamflow overall decrease during El Niño/PDO warm phase periods and increase during La Niña/PDO cool phase periods in the majority of China, although there are regional and seasonal differences. Precipitation and streamflow in the Yellow River basin, Yangtze River basin and Pearl River basin are more significantly influenced by El Niño and La Niña events than is precipitation and streamflow in the Songhua River basin, especially in October and November. Moreover, significant influence of ENSO on streamflow in the Yangtze River mainly occurs in summer and autumn while in the Pearl River influence primarily occurs in the winter and spring. The precipitation and streamflow are relatively greater in the warm PDO phase in the Songhua River basin and several parts of the Yellow River basin and relatively less in the Pearl River basin and most parts of Northwest China compared to those in the cool PDO phase, though there is little significance detected by Wilcoxon signed-rank test. When considering the combined influence of ENSO and PDO, the responses of precipitation/streamflow are shown to be opposite in northern China and southern China, with ENSO-related precipitation/streamflow enhanced in northern China and decreased in southern China during the warm PDO phases, and enhanced in southern China and decreased in northern China during the cool PDO phases. It is hoped that this study will be beneficial for understanding the precipitation/streamflow responses to the changing climate and will correspondingly provide valuable reference for water resources prediction and management across China.

Abstract. The ionospheric F2 peak height hmF2 is an important parameter that is much needed in ionospheric research and practical applications. In this paper, an attempt is made to develop a global model of hmF2. The hmF2 data, used to construct the global model, are converted from the monthly median hourly values of the ionospheric propagation factor M(3000)F2 observed by ionosondes/digisondes distributed globally, based on the strong anti-correlation existed between hmF2 and M(3000)F2. The empirical orthogonal function (EOF) analysis method, combined with harmonic function and regression analysis, is used to construct the model. The technique used in the global modelling involves two layers of EOF analysis of the dataset. The first layer EOF analysis is applied to the hmF2 dataset which decomposed the dataset into a series of orthogonal functions (EOF base functions) E k and their associated EOF coefficients P k . The base functions E k represent the intrinsic characteristic variations of the dataset with the modified dip latitude and local time, the coefficients P k represents the variations of the dataset with the universal time, season as well as solar cycle activity levels. The second layer EOF analysis is applied to the EOF coefficients P k obtained in the first layer EOF analysis. The coefficients A k , obtained in the second layer EOF analysis, are then modelled with the harmonic functions representing the seasonal (annual and semi-annual) and solar cycle variations, with their amplitudes changing with the F 10.7 index, a proxy of the solar activity level. Thus, the constructed global model incorporates the geographical location, diurnal, seasonal as well as solar cycle variations of hmF2 through the combination of EOF analysis and the harmonic function expressions of the associated EOF coefficients. Comparisons between the model results and observational data were consistent, indicating that the modelling Zhang (zhangml@mail.iggcas.ac.cn) technique used is very promising when used to construct the global model of hmF2 and it has the potential of being used for the global modelling/mapping of other ionospheric parameters. Statistical analysis on model-data comparison showed that our constructed model of hmF2, based on the EOF expansion method, compares better with the observational data than the model currently used in the International Reference Ionosphere (IRI) model.