From extracts of a hamster cell line transformed by the Simian virus 40, we have shown the presence of a factor that stimulates the replication of K virus and also counteracts the mechanism of action of interferon. The sensitivity of this factor to a proteolytic enzyme is a possible indication that we are dealing with a protein. This "stimulon" is unrelated to the T antigen as shown by chromatography on Sephadex G-100 and by complement fixation test. Furthermore, at 56 °C, all direct effects on virus K replication are lost but the anti-interferon activity is preserved.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.