Introduction: Acne vulgaris, a common dermatological disorder, is often associated with excess sebum production. Studies indicate acne and serum lipid profile pathophysiology and its association need further exploration. This study was done to evaluate the relationship and association between plasma lipid profile and acne. Materials and methods: A case-control study with group I containing 100 patients with acne vulgaris and group II containing 100 age-and gender-matched healthy volunteers as the control group. The lipid profile parameters were estimated in the cases and controls. Results: Serum total cholesterol, triglyceride, HDL, and LDL levels were measured. The predominant acne grade was grade II. Total cholesterol, triglyceride, and LDL levels were statistically higher than in the healthy control (significant with p < 0.05), whereas HDL level was insignificant. When lipid profiles between male and female were compared, there were no significant differences in both sexes between acne patients and controls. Total cholesterol, triglyceride, and LDL levels in patients with mild, moderate, and severe acne patients were statistically significant and correlated with the severity of acne. Conclusion: Acne patients are more frequently associated with altered lipid profile parameters, particularly with both moderate and severe acne. This deranged lipid parameters provide a new route for further exploration in the pathogenesis and also treatment aspects of acne vulgaris.
Abstract:Acne vulgaris is a common skin disease characterized by comedones, inflammatory lesions, secondary dispigmentation and scarring with a large impact on quality of life. There has been much debate as to whether liver function tests and lipids should be monitored while on therapy. The objective of the study is to evaluate the lipid profile changes in patients with moderate to severe acne on oral intermittent low dose isotretinoin therapy. Setting: Dermatology outpatient clinics, MIMS, Mandya. We included the 50 patients diagnosed with moderate to severe acne. All patients were treated with low dose isotretinoin and followed up in our outpatient clinics for 20 weeks. Patients were subjected to an interview questionnaire which included data on age, gender, previous treatment and liver enzymes. Blood analysis were repeated in the follow-up visits baseline, 4, 8,12,16, 20 weeks. Total cholesterol, triglycerides, HDL, LDL of 50 patients aged 15-40 years receiving isotretinoin for moderate to severe acne were monitored before, during and every month interval for 4 months. There was a statistically significant increase in the levels of total cholesterol, triglycerides, LDL with the decrease in the HDL level when compared with the baseline. The results in the study showed that the use of oral isotretinoin for the treatment of acne resulted in altered total cholesterol, triglycerides, LDL and HDL but the increase in the parameters is mild so as to not interrupt the treatment. Our study show that intermittent isotretinoin therapy has not much effect on the lipid profile and the adverse effects can be treated without interrupting the treatment.
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