Electronic poster abstractsfor 13 and 18 days respectively. After birth, both children presented with hypoglycemia, failure to thrive, body asymmetry, and evocative facial dysmorphism. Analyses confirmed hypomethylation of the H19 region in 11p15.5 for both. Now that Silver-Russell syndrome's phenotype and management are well described (international consensus statement published in 2017), our cases stress the importance of considering this diagnosis prenatally. This would allow appropriate counselling to parents and early postnatal specific management, including adequate nutrition and consideration for growth hormone therapy. In searching a way to improve diagnostic test sensitivity for fetal acidemia in IUGR fetuses we have explored diastolic function of the fetal heart looking for dysfunction of the diastolic active relaxation time of the ventricle that depends on adenosine triphosphate. Like some adults heart disease. Based on a previous report which showed correlation of ductus venosus v wave and heart dysfunction another reports of progressive increment on B natriuretic peptide in IUGR. We did an exploratory case series in which we evaluated right ventricle diastolic function based on right AV spectral Doppler wave analysis and right ventricle tissue Doppler at level of annulus. Also analysis of ductus venosus. We find a IUGR case diagnosed at 28 weeks with 4 centile weight estimation with normal fetal Doppler and pulsatility index of uterine artery above 95 centile. Two weeks after estimated weight was under 3 centile. The findings are depicted in supplemental material. Amniotic fluid was normal. Non stress test not performed. Fetal breathing movements not recorded. The mother enter the hospital the day after. Because non stress test with late decelerations the day after, the obstetrician perform a Caesarean section. The newborn weighed 1100 grams, Apgar 7-8, umbilical artery ph 7.0 and base deficit -12. The only newborn complication was hialine membrane disease. Placental byopsy showed chorangiosis. Conclusions: In this case with probably low vascular resistance in fetal side of placenta because chorangiosis Ductus venosus a wave flow reversal did not correlated well with low pH value obtained the day after, unlike direct diastolic dysfunction assessment and pulsatility index of Ductus Venosus. This is an example of the importance of an integrated IUGR assessment, that should include always biophysical and Doppler parameters. And perhaps as in this case, right ventricle diastolic function analysis. EP14.40 EP14.42Fetal cerebrorenal ratio and cerebroplacental ratio to evaluate the small fetus Objectives: Brain sparing results from a decreased impedance to flow in the brain and a increased impedance to flow in the peripheral vasculature. We compare the cerebral to renal artery pulsatility index ratio (CRR) with the cerebral placental ratio (CPR) among AGA and SGA fetuses. Methods: Women with EFW >10th percentile were compared with those <10th percentile. The proportion of women with CRR or CPR below the 5t...
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