From an analysis of published sibships containing at least one subject with Huntington's disease, evidence was obtained from segregation ratios derived from several hypothetical modes of ascertainment that single‐membered sibships are less likely to be recorded than those containing at least two affectcd persons and that the probability of reporting a sibship is proportional to the number of affected siblings. Familial sex‐limitation and partial sex‐linkage could not be detected in the sample. Investigation of parental and grandparcntal lines ol transmission revealed that patrilineal descent predominated for all subjccts except unaffected daughters. Mcan ages at onset and death wcrc independent of the 5ex of the subject or the tranymitting parent. On the other hand, the offspring of affected males suffered from the disorder for a shorter period of time than offspring of affccted females. Ages at onsct and death varied significantly from generation to generation, presumably because parents are ofren ascertained through their children in the literature and the phenomenon of anticipation thereby arises. Onset age was earlier in members of small sihships than in those of large sibships. This could be related to the earlier onset age of parents producing small families compared with those producing large families.
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