SUMMARYHoney bee venom (HBV) administration to adjuvatii arthritic (AA) rats resulted in a significanl suppression of arthritis and in suppression ofthe hepiitie acute phase ai-acid glycoprotein (AGP) gene induction at lhe early stages of disease development. AGPadniinislrationin A A rals resulted in acceleration of arthritis development and in increase of severity and duration of the disease, lL-1, IL-6. tumournecrosisfiictor(TNF)andglucocorticoidsalonearenol responsible for Ihc HBV-nicdiaied AGP gene down-regulation. These results indicate that AGP gene expression in A A and H B V-ireated AA rals involves Ihe intcraclion of several factors, and that AGP plays a role for AA development in rats.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.