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The management of solid waste is currently seen as one of the most important concerns that national authorities, particularly in south Europe, must address. In recent years, emphasis has begun to be paid to Construction and Demolition Waste (CDW) being the largest waste stream in the European Union that is produced by renovation and repair work on buildings, roads, bridges, and other constructions made of bulky materials such as asphalt, bricks, wood, and plastic. Many EU countries responded quickly as a result of the large amounts of such waste and the presence of hazardous substances in their composition. This study illustrates the anticipated outcomes of several CDW management strategies other than final disposal, such as recycling, reuse, and incineration, for a public-school building in Greece. In order to assess how well the chosen schemes performed in terms of various environmental criteria, the SimaPro software suite and the Ecoinvent v.3 Life Cycle Inventory database were used. In order to enhance the quality of the outcomes, inventory data from earlier studies were also employed as input data for the Life Cycle Assessment tool.