Dear Editor, Costello syndrome is a rare genetic syndrome. The mode of inheritance is autosomal dominant; however, most cases are sporadic. Mutations in the HRAS gene lead to a dysregulation of the Ras/mitogen-activated protein kinase (MAPK) pathway. 1 These genetic diseases are known as RASopathies and include Costello syndrome, LEOPARD syndrome, Noonan syndrome, cardiofaciocutaneous syndrome, neurofibromatosis type 1 and Legius syndrome. Patients with RASopathies often suffer from mental retardation, cardiovascular disease, short stature, macrocephaly

We report 20 newborns who developed, at a median age of 7 days, large abdominal patches of radially arranged purplish telangiectasia in a bilateral and symmetrical pattern in relation to the midline, creating a "butterfly wing" pattern. Clinical examination was normal in 13 newborns, six newborns had abdominal distention, and one newborn had poor weight gain due to inadequate breastfeeding. Most lesions spontaneously resolved within 3 months and did not reoccur for 19 newborns. Transient abdominal telangiectasia of the newborn (TATN) appears to be a distinctive entity that has not been previously described.

No abstract

No abstract

No abstract