Oxyntomodulin (OXM) is a peptide isolated from porcine intestine which consists of the whole glucagon sequence with a basic octapeptide (KA,) at its C-terminal end. In this study, the effect of OXM and KAB on pentagastrin-stimulated gastric acid secretion has been studied in conscious rats and cats. In rats, OXM (25-450 pmol . kg-') as well as KA, (7.5-40 nmol ' kg-l) inhibited ~ntagast~n-stimulate gastric acid output in a dose-dependent manner; KA, was about IOO-times less potent than OXM. In cats, KA, (90 nmol . kg-') was also an inhibitor of acid secretion. We conclude that OXM, or a closely related peptide, could be a physiological modulator of gastric acid secretion, and that the C-terminal octapeptide of OXM is implicated in this effect.
Uxyntomod~ii~ Rat Cat
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