A rise in systolic blood pressure due to the administration of 0.4 or 0.5 μg of aldosterone per 100 g body weight to young male rats, over a period of 3 to 6 months, has been confirmed in two separate experiments. This effect was observed whether the aldosterone was given 3 days a week or 6 days a week, and whether dissolved in aqueous ethanol or in oil. Equal doses of 9-α-fluorohydrocortisone and of 2-methyl-9-α-fluorohydrocortisone produced similar though somewhat less consistent effects. When 4 or 5 μg of reserpine was administered along with aldosterone there was no clear evidence of a protective effect. Reserpine alone at these low dose levels was somewhat toxic in the rat and led to a rise in blood pressure.
A rise in systolic blood pressure due to the administration of 0.4 or 0.5 μg of aldosterone per 100 g body weight to young male rats, over a period of 3 to 6 months, has been confirmed in two separate experiments. This effect was observed whether the aldosterone was given 3 days a week or 6 days a week, and whether dissolved in aqueous ethanol or in oil. Equal doses of 9-α-fluorohydrocortisone and of 2-methyl-9-α-fluorohydrocortisone produced similar though somewhat less consistent effects. When 4 or 5 μg of reserpine was administered along with aldosterone there was no clear evidence of a protective effect. Reserpine alone at these low dose levels was somewhat toxic in the rat and led to a rise in blood pressure.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.