Results suggest that use of cyclophosphamide and bovine hemoglobin solution in treatment of idiopathic immune-mediated hemolytic anemia may be associated with increased risk of death.

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Letters to the Editor tration was 87 g/l, platelet count was 123 x 10'/l and lactic dehydrogenase was 939 U/1. Surface membrane markers were identified by indirect immunofluorescence and examined with a FACScan flow cytometer (Becton Dickinson, Mountain View, California, USA). The following antibodies were analysed: T3, T4, T8, J5, B4, Bi (Coulter Clone); LeuM5, Leul5, Leul4, IL-2, Leul7 and Leu8 (Becton Dickinson); anti-LFA 1 and anti-fLFA lB (Janssen); Cris 1 (Dr R Vilella, Hospital Clinic Provincial, Barcelona); FMC7 (Sera-Lab); IOB8 (Immunotech); and surface immunoglobulins (Kallestad). Mouse rosettes were also sought. Detailed results are shown in the table. B cell chronic lymphoid leukaemias comprise a broad spectrum of lymphoid proliferations classified according to the cytological and phenotypic features of the leukaemic cells.' Our case was a mantle zone

Archives ofDisease in Childhood 1995; 73: 184 for those at the extremes of the normal range for fat/thin, short/tall, clever/stupid, clumsy/ agile, white/black individuals? My own puberty was late. Not much fun at the time but the resultant temporary exclusion from full membership of the peer group has produced a useful long term lesson in coping with the natural ups and downs of life. Explanation, empathy, and reassurance are in my view better medicine in this area, as in many others, than use of medication.