Alabama in Birmingham, Alabama 35294, USA J Dent Res 57(2): 244, February 1978We report here the pre-eruptive as well as posteruptive effects of large doses of vitamin E on experimental caries in rats. The study was initiated by feeding semi-purified diets containing 3 different levels of vitamin E to 15-day pregnant Sprague-Dawley rats (6-9/group). The basal diet was cariogenic diet, MIT 200 (NAVIA, LOPEZ and HARRIS, J Nutr 79:133, 1969) but without any vitamin E added. Tocopherol-stripped lard* was substituted for cotton-seed oil; dl -ceTocopherol powder* (1 gm = 250 IU as oa-Tocopherol acetate) was added to the basal diet at 0, 0.1 and 1.0% level so that the diets contained 0, 250, and 2,500 IU of vitamin E/Kg. One day after birth, the pups in each group were randomized to form foster litters, each containing 8 pups (4 male and 4 female). Feeding same diets to foster mothers was continued until the pups were weaned at 19 days of age. After weaning, young rats (40 per group) were housed in separate, wire-bottom cages and were fed ad libitum the same diets which had previously been fed to
Using a standardized guinea pig model system, the histologic appearance of newly formed bone from vitamin A deficient, vitamin A adequate and retinoic acid treated animals was compared. Microscopic examination of the histologic sections of bone collected from vitamin A deficient guinea pigs indieated the presence of highly cellular and loosely woven bone spicules. This model system is an osteoblastic model, sinee osteoclasts are essentially absent in tissue formed in 14-day implants. Thus, new bone formation in the vitamin A deficient guinea pig reveals morphologic changes which are principally mediated through the osteoblastie proeess.
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