A report is presented of a woman with Turner's syndrome who subsequently developed acromegaly. An eosinophil adenoma of the hypophysis was diagnosed, and removed by operation. Although there was an excess of natural growth hormone, the patient no longer showed longitudinal growth, and the epiphyseal lines were not closed. It was consequently considered that the retardation of longitudinal growth in Turner's syndrome is a result of insensitivity of the bone tissues to growth hormone.
It is well known that stimulation, by progesterone, of the formation of a \p=>>\progestational\p=<<\ endometrium is enhanced by pretreatment with oestrogen. As early as 1928, shortly after the discovery of the corpus luteum hormone, Weichert observed that deciduomata of the traumatized uterus developed only if treatment of the rats with corpus luteum extract had been preceded by the administration of follicular hormone. In 1930, Hisaw & Leonard confirmed these results in rabbits. Shelesnyak (1933) was one of the first to emphasize the importance of an optimal ratio between the doses of both hormones. De Fremery & Geerling (1939) found 0.6 mg. of progesterone daily, preceded by 15 \g=m\g. of oestrone or stilboestrol to be the most effective combination. Korenchevsky & Hall (1937) found daily doses of 1 \g=m\g. of oestrone followed by 1.5 mg. of progesterone to be even more active than 30 \g=m\g. of oestrone followed by 3 mg. of progesterone.There are other results, however, which show that under certain conditions oestrogen pretreatment is not essential. Moricard 8c de Senarclens (1949) ob¬ tained negative results in spayed, immature rabbits with 2.5 mg. of progesterone over a three days' period; in recently spayed adult animals, however, a typical »dentelle utérine« developed. In this case, oestrogen may have played its part before gonadectomy. Selye (1940) obtained real progestational effects without oestrogen pretreatment by administering very large doses of progesterone (15 mg. daily) to adult spayed rats. Howard 8c Gengradon (1940) report similar results obtained in mice with 1.5 mg., a high dose for this species. Korenchevsky 8c Hall (1937) observed in adult spayed rats atypical alterations in the uterine Supported by a grant from the foundation »De drie Lichten«.
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