The synthesis of 4,4,5,5-tetradehydro and cis-4,5-didehydro prostacyclin analogues is described. The separation of the 6a and 6/3 isomers has been easily achieved at an early stage of the synthesis. The configuration of the 6a and 6¡S isomers has been determined by conversion of those isomers into 13,14-dihydro-6a-PGIi and 6/3-13,14-dihydro-6/8-PGIi, respectively, via catalytic hydrogenation and correlation of the TLC mobilities of these isomers with authentic 13,14-dihydro-6a-PGI1 and 13,
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