& d a g g e r ; Winthrop Laboratories.As testosterone and its derivatives camẽ iLS testosterone and its derivatives came to be used for their androgenic effect, and later for cancer of the breast, it soon became apparent that many patients had general clinical improvement which seemed attributable to the anabolic activity of these steroids. The increases in weight, appetite, and hemoglobin and serum albumin levels, all highly desirable feature that go along with increased vigor, strength and sense of well-being, were side effects which opened up a promising new area of application. Such new uses were hampered, however, by the strong androgenic qualities. It was logical, therefore, that the pharmacologic chemists should extend their efforts to produce related new steroids that were more anabolic and less androgenic. These labors resulted in several new compounds that have met with varying success in their clinical application.12 Androgenicity, salt retention and occasional jaundice due to cholangitis, still limit the clinical usefulness of some of these products.The new anabolic steroid, stanozolol t ( Fig.
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