[3H]-salbutamol added in tracer doses (~ 250 nmol per animal) to the carrier
solution (20 mg/kg) was injected intraperitoneally to pregnant rats on the 19th day of
gestation. Some experiments were performed with intravenous administration (~ 2.5 µCi
in 300 µl 9 g/1 NaCl). Drug distribution was studied in the maternal and fetal plasma, lung
and liver, and in the placenta and amniotic fluid. 10% of the maternal salbutamol plasma
radioactivity was recovered in the fetal plasma, in accordance with earlier findings
reported from our laboratory using human placental lobules in vitro.
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