Table of contentsP001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP effluxR. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. EllisP002 - Lower serum immunoglobulin G2 level does not predispose to severe flu.J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez GallegoP003 - Brain protective effects of intravenous immunoglobulin through inhibition of complement activation and apoptosis in a rat model of sepsisF. Esen, G. Orhun, P. Ergin Ozcan, E. Senturk, C. Ugur Yilmaz, N. Orhan, N. Arican, M. Kaya, M. Kucukerden, M. Giris, U. Akcan, S. Bilgic Gazioglu, E. TuzunP004 - Adenosine a1 receptor dysfunction is associated with leukopenia: A possible mechanism for sepsis-induced leukopeniaR. Riff, O. Naamani, A. DouvdevaniP005 - Analysis of neutrophil by hyper spectral imaging - A preliminary reportR. Takegawa, H. Yoshida, T. Hirose, N. Yamamoto, H. Hagiya, M. Ojima, Y. Akeda, O. Tasaki, K. Tomono, T. ShimazuP006 - Chemiluminescent intensity assessed by eaa predicts the incidence of postoperative infectious complications following gastrointestinal surgeryS. Ono, T. Kubo, S. Suda, T. Ueno, T. IkedaP007 - Serial change of c1 inhibitor in patients with sepsis – A prospective observational studyT. Hirose, H. Ogura, H. Takahashi, M. Ojima, J. Kang, Y. Nakamura, T. Kojima, T. ShimazuP008 - Comparison of bacteremia and sepsis on sepsis related biomarkersT. Ikeda, S. Suda, Y. Izutani, T. Ueno, S. OnoP009 - The changes of procalcitonin levels in critical patients with abdominal septic shock during blood purificationT. Taniguchi, M. OP010 - Validation of a new sensitive point of care device for rapid measurement of procalcitoninC. Dinter, J. Lotz, B. Eilers, C. Wissmann, R. LottP011 - Infection biomarkers in primary care patients with acute respiratory tract infections – Comparison of procalcitonin and C-reactive proteinM. M. Meili, P. S. SchuetzP012 - Do we need a lower procalcitonin cut off?H. Hawa, M. Sharshir, M. Aburageila, N. SalahuddinP013 - The predictive role of C-reactive protein and procalcitonin biomarkers in central nervous system infections with extensively drug resistant bacteriaV. Chantziara, S. Georgiou, A. Tsimogianni, P. Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, G. Micha, E. Chinou, G. MichaloudisP014 - Changes in endotoxin activity assay and procalcitonin levels after direct hemoperfusion with polymyxin-b immobilized fiberA. Kodaira, T. Ikeda, S. Ono, T. Ueno, S. Suda, Y. Izutani, H. ImaizumiP015 - Diagnostic usefullness of combination biomarkers on ICU admissionM. V. De la Torre-Prados, A. Garcia-De la Torre, A. Enguix-Armada, A. Puerto-Morlan, V. Perez-Valero, A. Garcia-AlcantaraP016 - Platelet function analysis utilising the PFA-100 does not predict infection, bacteraemia, sepsis or outcome in critically ill patientsN. Bolton, J. Dudziak, S. Bonney, A. Tridente, P. NeeP017 - Extracellular histone H3 levels are in...
Giant cell myocarditis (GCM) is a rare and frequently fatal disorder. Patients suffer of ventricular arrhythmias or congestive heart failure. Here we describe a patient with cardiogenic shock and histological verified GCM. The patient was saved by implantation of extracorporeal membrane oxygeneation (ECMO) device and concomitant application of Rabbit antithymocyte globuline (rATG, Thymoglobulin, Sangstat), cyclosporine, and steroids in the acute event. 12 months after the crisis the patient evidences NYHA class I heart function and only a moderate impairment of heart function (EF 55%). The novel utilisation of ECMO in GCM related cardiogenic shock and application of rATG have prooven life-saving in this patient. Studies utilizing rATG in the treatment of GCM are warrented.
P ostoperative hemorrhage in neurosurgery is associated with substantial morbidity and mortality. In the final phase of clot formation, thrombin activates fibrinogen to form a hemostatic fibrin clot that is additionally stabilized via cross-linking by coagulation factor XIII (FXIII). Whether FXIII deficiency leads to bleeding complications after craniotomy is still a subject of controversy. This prospective observational study was undertaken to determine perioperative fibrinogen and FXIII levels in patients having elective intracranial surgery with and without severe bleeding events postoperatively.The 290 patients were separated into those who had or did not have severe bleeding that required surgical revision. Patients had the surgery using a standard protocol with a balanced crystalloid solution used for fluid maintenance therapy. Additional volume therapy was provided with a balanced colloid or albumin and blood products or coagulation factor concentrates. Hemoglobin concentration of 8 g/dL was the trigger for packed red blood cell (RBC) transfusion. In the intensive care unit, all patients underwent neurologic testing and cerebral computed tomography or magnetic resonance imaging scans to screen for postoperative hematoma. Low-molecular-weight heparin enoxaparin was used for thromboprophylaxis (40 mg subcutaneously once a day) after postoperative bleeding was ruled out. Coagulation parameters and fibrinogen levels were determined. The perioperative estimated blood loss (EBL) was calculated and adjusted for the perioperative use of RBC concentrates. The main outcomes were the perioperative fibrinogen and FXIII levels in patients with and without severe postoperative bleeding within 48 hours after surgery. Secondary outcomes were the association between coagulation parameters and bleeding and the predictive power of coagulation factor levels for severe bleeding events. Data were analyzed using IBM SPSS Statistics for Mac, version 20.0 (IBM Corp., Armonk, NY). P < 0.05 indicated statistical significance.Seven (2.4%) of the 290 patients required surgical evacuation of a postoperative hematoma. Preoperative fibrinogen levels were within the reference range and did not differ between the hematoma group and those without hematoma. A fibrinogen concentration of 200 mg/dL was the cutoff value between the 2 groups with a sensitivity of 86% and a specificity of 62%. The postoperative mean (±SD) fibrinogen levels were 237 ± 86 mg/dL in the hematoma group compared with 170 ± 35 mg/dL the nonhematoma patients (P = 0.03). Six of the 7 patients in the hematoma group (86.0%) had a postoperative fibrinogen level of less than 200 mg/dL compared with 106 (38.0%) of 283 without hematoma (P = 0.01). A fibrinogen level of less than 200 mg/dL postoperatively was associated with bleeding (odds ratio, 10.02; 95% confidence interval, 1.19-84.40; P = 0.03). Fibrinogen levels decreased by a mean of 11% ± 13% from baseline during surgery with an absolute median decrease of −30 mg/dL (P < 0.01). The perioperative decrease in fibrinogen le...
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