synopsisPoly(a,cr,a',a'-tetrafluoro-p-xylylene) was prepared by the pyrolysis of cyclo-di- (a,a,a',a'-tetrafluom-p-xylylene) and by the pyrolysis of a,a'-bis(alkylsulfony1)-a,a,a',a'-tetrafluoro-pxylene. The pyrolysis of a,a'-dibromo-a,a,cr',a'-tetrafluoro-pxylylene also gave the polymer, but the method is less satisfactory. Poly(a,a,a',a'-tetrafluoro-pxylylene) shows remarkable thermal and oxidative stability at elevated temperatures. Useful mechanical and electrical properties are retained after aging for 3000 hr at 250' in air. After initial change due to crystallization, tensile strength remains near 10,000 psi, elongation above 5%, and dielectric constants and dissipation factors at approximately 2.4 and .001, respectively.
There are a limited number of stimuli-responsive biomaterials that are capable of delivering customizable dosages of a therapeutic at a specific location and time. This is especially true in tissue engineering and regenerative medicine applications, where it may be desirable for the stimuli-responsive biomaterial to also serve as a scaffolding material. Therefore, the purpose of this study was to engineer a traditionally non-stimuli responsive scaffold biomaterial to be thermally responsive so it could be used for on-demand drug delivery applications. Fibrin hydrogels are frequently used for tissue engineering and regenerative medicine applications, and they were functionalized with thermally labile oligonucleotide tethers using peptides from substrates for factor XIII (FXIII). The alpha 2-plasmin inhibitor peptide had the greatest incorporation efficiency out of the FXIII substrate peptides studied, and conjugates of the peptide and oligonucleotide tethers were successfully incorporated into fibrin hydrogels via enzymatic activity. Single-strand complement oligo with either a fluorophore model drug or platelet-derived growth factor-BB (PDGF-BB) could be released on demand via temperature increases. These results demonstrate a strategy that can be used to functionalize traditionally non-stimuli responsive biomaterials suitable for on-demand drug delivery systems (DDS).
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