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Exocrine pancreatic function was assessed in 588 subjects by oral administration of 1 g of the chymotrypsin-labile peptide N-benzoyl-L-tyrosyl-p-aminobenzoic acid (Bentiromide) from 1974 to 1979. The pancreatic function test (PFT) was performed in 126 controls, 217 patients with pancreatic diseases, 196 patients with various non-pancreatic gastrointestinal disease, 18 patients with renal disease and 31 patients with various other diagnoses. In 62 of 72 patients (86 per cent) with chronic pancreatitis and in 19 of 25 (76 per cent) with pancreatic carcinoma, the excretion of p-aminobenzoic acid (PABA) in the urine was significantly less than in the controls. In contrast, 328 of 353 controls and patients with non-pancreatic diseases (93 per cent) had PABA excretion within normal limits. The sensitivity and specificity of the Bentiromide-test observed in this study is sufficient to detect moderate to severe disturbances of pancreatic exocrine function. The PFT has proved to be an easy and reliable screening test for pancreatic exocrine function in ambulatory as well as in hospitalized patients.

Summary: The oral pancreatic function test with N-benzoyl-Z,-tyrosyl-p-aminobenzoic acid was performed on 24 healthy test subjects, and its toxicity was examined. Eight patients with restricted renal function and known renal disease were also investigated. The pancreatic function test and the same procedure using free p-amino-benzoic acid were performed at 2-3-day intervals.During all the investigations with the pancreatic function test, no clinical side effects were observed. All parameters investigated at all the test times fell within the normal range. No toxicity of N-benzoyl-Z,-tyrosyl-p-aminobenzoic acid could be found. The excretion ofp-aminobenzoic acid after administration of N-benzoyl-£-tyrosyl-paminobenzoic acid was greatly reduced in all patients with restricted renal function. Four of eight patients also showed essentially no increase in excretion rate when free p-aminobenzoic acid was given instead of the pep tide. It is therefore not possible to correct the pancreatic function test results in patients with renal insufficiency by calculating the ratio of p-aminobenzoic acid excretion after peptide intake to that after free p-aminobenzoic acid ingestion. Adequate renal function is therefore a prerequisite for the pancreatic function test. Der orale Pankreas-Funktions-Test mittels N-Benzoyl-L-tyrosyl-p-aminobenzoesäure: Akute Toxizität und Beeinflussung durch die Nierenfunktion

SUMMARY In a total of 71 subjects (19 controls, 24 patients with non-pancreatic gastrointestinal disease, and 27 patients with pancreatic disease) an oral pancreatic function test using N-benzoyl-L-tyrosyl-PABA (BT-PABA) was performed with simultaneous determination of the serum para-aminobenzoic acid (PABA). Urinary excretion of PABA was significantly less (p

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