The preliminary results of a cytogenetic analysis of blast index, mitotic index and association index, as well as of morphological indices of chromosomes 1, 9 and 16, carried out on two subsamples of twin pairs of different age groups, seem to indicate that the genetic material may undergo some process of transformation with time.
A case of double bilateral renal vessels in both twins of a MZ pair is reported for the first time. Even in non-twins, the anomalies reported so far involved the inferior polar arteries in agreement with the embryological development. The two male twins, examined at the age of 14 years, had simultaneously developed a marked hypertension at the age of 7 years. Zygosity was determined by blood group and HLA analysis and various clinical tests were carried out to diagnose the condition. It is suggested that the anomaly is the result of a genetically induced early block in embryonic development.
The results of a study on the chromosome association index carried out on a sample of singletons and on a sample of MZ and DZ twins, all of different age groups, lead to tentatively conclude that the reduced efficiency of mitotic genotypes, as reflected by the phenomenon of association, is genetically conditioned.
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