Platelet aggregation was studied in 40 children with previously untreated ALL. The studies were performed in 5 groups: during the two-phase m-Ultiple drug induction therapy, the three phases of cyclic sequential maintenance therapy (6-MP, MTX and VCR/PRED pulses) and after cessation of chemotherapy (Klin. Padiat. 189: 89, 1977).There was a significant inhibition of the collagen-induced platelet aggregation (p <0. 001) during the two months' period of induction chemotherapy. By the use of ADP as platelet aggregating agent the impairment of function was less evident (p < 0. The alteration of platelet function persisted during the first cycle of maintenance therapy (6-MP) and reappeared regularly during the VCR/PRED pulses to a lesser degree (p
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