CARBOHYDRATE OXIDATION. I 3085 the solution filtered. The filtrate was cooled to 0°and very carefully neutralized with cold hydrochloric acid. The crystalline material so obtained was rapidly filtered off and washed several times with ice water; yield, 60%. The product was purified by crystallization from alcohol or preferably from benzene.Four g. of ethyl-vinyloxyethyl-barbituric acid, prepared as described above, was placed in 30 cc. of hot water, in which it is insoluble. On the addition of 2 cc. of hydrochloric acid and stirring, the solid dissolved almost immediately while the acetaldehyde formed by the hydrolysis was removed by boiling. The product crystallized on cooling and was purified by crystallization either from alcohol or water; yield of ethyl-d-hydroxyethyl-barbituric acid, 70%. Summary 1. A method for the preparation of hydroxy-substituted alkyl-barbituric acids has been described.2. The compounds so prepared may be hypnotics with properties similar to those of veronal and proponal, and should be less toxic. The result of a study of their pharmacology will be reported later.
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