No abstract

Teichomycin (teicoplanin) was found to be a mixture of five closely related components of similar polarity, designated T-A2-1, 2, 3, 4 and 5 and of one more polar component, designated T-A3. The separation of the single components was achieved by reverse phase partition chromatography and their physico-chemical and biological properties were compared. The results show that 1) the five major components have the same molecular size of about 1,900; 2) they contain the same ionizable functions, i.e., a carboxyl group and an amino group which form a zwitterion, and four phenolic groups; 3) they differ in a side aliphatic chain. The component T-A3 is not described. Teichomycin** is a glycopeptide antibiotic produced by Actinoplanes teichomviceticus nov. sp. ATCC 31121•''. It is active against aerobic and anaerobic Gram-positive bacteria and it is under evaluation for use in man". The major characteristics differentiating teichomycin from the other members of the glycopeptide antibiotics') is the sugar composition, i.e., the presence of D-mannose and D-glucosamine2), while the chlorinated product obtained by oxidation seems to indicate similarities to vancomycin3>. It is worthwhile to recall that the antibiotic produced by fermentation was initially re

The teichomycins are new antibiotics produced by Actinoplanes teichomyceticus nov. sp.

No abstract

No abstract