Gammopathies were found to be present in 25 0.3%) of 192 HIV-negative renal transplant recipients ~Ith more than 30 months follow-up prospectively inves-?gated for monoclonal or oligoclonal immunoglobulins Emlg) by agarose gel electrophoresis and immunofixation. 1 leven patients had only one monoclonal band, whereas 4 had two or more bands. Of these bands, 60% were IgG kappa, 29% IgG lambda and 11 % IgM lambda or kappa, and 90% did not exceed 2 g/1. Most gammopathies occurred early post-transplant (median 5 months) and they Were always transient. Some predisposing factors for mig ~mergence could be identified: 1. age, but only in women, :duration of dialysis, 3. occurrence of prior cytomegalo-Vtru~ infection, and 4. immunosuppressive regimen in-l~dmg cyclosporine. Serological evidence for active EBV } 0 e~tion was obtained in ten patients, but in six cases in-ec~ton occurred subsequent to the finding of mig. In eight
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