present our experience in liver transplantation in a series of 22 patients with unresectable bilateral hepatic metastases of neuroendocrine tumors and with previous resection of the primary tumor. Methods: We retrospectively reviewed the medical records of 22 patients (12 men and 10 women), with a mean age of 49,7 years, who underwent liver transplantation due to bilateral neuroendocrine liver metastases with previous resection of the primary tumour during 21 years. The most frequent location of the primary tumor was the pancreas in 13 patients (2 carcinoid, 3 gastrinoma, 1 glucagonoma and 8 non-functioning tumors). The remaining 9 tumors were located in the small bowel (7) and in the lung (2). Results: Only 1 patient died due to technical complications related to the transplant, representing a mortality rate for the entire group of 4,5 %. After a median follow-up of 11 years (range: 1 month-21 years), two patients died due to tumoral recurrence at 15 and 17 months. The survival rate at 3 and 5 years was 86% and 57%, respectively. Conclusions: In our series, the results the liver transplantation in the management of unresectable neuroendocrine liver metastases indicate that careful patient selection is required. The key to obtaining good results is individualization of the indication for this procedure.
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