Limbic modulatory influences on hypothalamic adrenocorticotropic activity were investigated by means of electrical stimulation through chronically implanted deep electrodes in the conscious unrestrained pigeon, and by means of bilateral electrolytic lesions. Hippocampal stimulations or lesions were found to induce either a marked drop or rise in plasma corticosterone concentration. Archistriate stimulation ted to an increase of corticosterone (B) titer. Diurnal variations in corticoid level were suppressed after lesion placement in the hippocampus, but stress-induced responses were only slightly reduced. No behavioral signs were detected during and after periods of stimulation.
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