The records of 50 cerebellar haemorrhages were reviewed retrospectively. In this series the most important factor for clinical development, management and mortality was the presence of obstructive hydrocephalus (p < 0.01). Slowly progressive (type 1) and abruptly developing (type 2) deterioration of consciousness was significantly related to high mortality; this holds also true for the combination of hydrocephalus with an haematoma diameter > 3 cm. Larger haematomas had a higher mortality but this relation, analyzed alone, did not reach statistical significance (p > 0.05). In cases with hydrocephalus mortality could significantly be reduced by surgical evacuation of the haematoma (p < 0.01). The treatment of cerebellar haemorrhages must be directed at resolving obstructive hydrocephalus.
SUMMARY In acute experiments performed in cats under ethyl urethane anaesthesia, bilateral epileptic foci were created on the sigmoid gyri of both cerebral hemispheres. Confirming previous observations, the 2 foci were found to discharge synchronously. Bilateral synchronization was present as well between the epileptic discharges propagated to the intralaminar thalamic nuclei and midbrain reticular formation. Splitting of the corpus callosum and hippocampal commissure disrupted bilateral synchrony of epileptic discharges. The latter could be restored by increasing the intensity of epileptic activity. Additional split of the diencephalon (anterior commissure, massa intermedia and hypothalamus) again disrupted epileptic bilateral synchrony. The latter could still reappear following further increase of epileptic activity. Finally, split of midbrain tectum and tegmentum eradicated bilateral synchrony of epileptic potentials. It is stressed that in the brain‐split animals bilateral synchronization of the epileptic discharges can reappear only if the convulsive activity of the 2 cortical foci is strong enough to propagate subcortically to the intralaminar thalamic nuclei and midbrain reticular formation. The possible role of the non‐specific brain structures in mediating the bilateral synchrony in the animals lacking the telencephalic and diencephalic commissures is suggested and discussed. RÉSUMÉ Des foyers épileptogènes bilatéraux ont été effectués chez le chat anesthésié avec l'éthyl‐urétane, sur le girus sigmoïdeux des deux hémisphères (expériences aiguës). En accord avec les précédentes données expérimentelles, les décharges des 2 foyers étaient synchrones; les décharges propagées aux noyaux intra‐laminaires thalamiques et à la formation réticulaire mésencéphalique étaient aussi synchrones. La section longitudinelle du corpus callosum et de la commissure de l'hippocampe supprimait la synchronic bilatérale. Cette synchronic réapparaissait quand l'activitéépileptique devenait plus intense. La synchronic était de nouveau perdue avec la section longitudinelle du diencéphale (commissura anterior, massa intermedia et hypothalamus). Cette fois aussi on pouvait avoir encore une synchronic si l'activitéépileptique devenait plus intense. Enfin, la synchronic des décharges épileptiques disparaissait en façon définitive avec la section longitudinelle du tectum et du tegmentum mesencéphaliques. On souligne l'importance du fait que chez les animaux qui avaient été sectionés, la synchronic des décharges épileptiques de 2 foyers corticaux pouvait réapparaître seulement lorsqu'il y avait une propagation aux noyaux thalamiques intralaminaires et à la formation réticulaire mesencéphalique. On discute la possibilityé du rôle des structures non spécifique dans le mécanisme de la synchronie bilatérale de l'activitéépileptique.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.