To evaluate associations between the domains of the ANCA-associated vasculitis patient-reported outcome (AAV-PRO) instrument and clinical variables. Patients with granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), or renal-limited vasculitis (RLV) were recruited from a tertiary care center in Mexico City. Demographic, clinical, serological, and treatment-related data were retrieved. Disease activity, damage, patient and physician global assessments (PtGA and PhGA) were evaluated. All patients completed the AAV-PRO questionnaire, male patients also completed the International Index of Erectile Function (IIEF-5) questionnaire. Seventy patients (44 women and 26 men) were included, with a median age of 53.5 years (43–61), and a disease duration of 82 months (34–135). Moderate correlations were identified between the PtGA and the AAV-PRO domains: social and emotional impact, treatment side effects, organ-specific symptoms, and physical function. The PhGA correlated with the PtGA and prednisone doses. Subanalyses of the AAV-PRO domains according to sex, age, and disease duration showed significant differences in the treatment side effects domain, with higher scores in women, in patients < 50 years, and in patients with disease duration < 5 years. The domain of concerns about the future showed a higher score in patients with disease duration < 5 years. A total of 17/24 (70.8%) of men who completed the IIEF-5 questionnaire were classified as having some degree of erectile dysfunction. The domains of AAV-PRO correlated with other outcome measures, while differences were found between some of the domains according to sex, age, and disease duration.
Supplementary Information
The online version contains supplementary material available at 10.1007/s00296-023-05288-4.
examining its use in patients with Peyronie's disease (PD). The objective of this study was to explore the use of the SSIPI in men with PD and to determine if any factors predict postoperative outcomes in specific domains.METHODS: Preoperative, intraoperative, and postoperative data for patients with PD undergoing IPP placement by a single surgeon at a tertiary care institution was retrospectively collected into a secure database. A completed SSIPI from either the 3, 6, or 12 month follow up visit was used. Linear regression and Fischer's exact test was used to determine if there were any significant relationships between variables and the four subdomains for each patient.RESULTS: Within the study time period, 32 patients with PD who received an implant completed a postoperative SSIPI. Average curvature preoperatively was 44.8 degrees. Overall postoperative median SSIPI scores was 4.5 (IQR 4.2 e 4.8). There was no significant difference in the subdomains between the two different implants used which were the Coloplast Titan (n[23) and the AMS 700 CX (n[9). Of the preoperative variables assessed, only body mass index was significantly negatively correlated with the appearance domain of the SSIPI (slope[-0.06, R 2 [0.20, p[0.018). Of the categorical variables, those patients with a subjectively difficult dilation had a significantly higher score in the pain domain (p[0.046) indicating less pain postoperatively.CONCLUSIONS: This is the first study to use the SSIPI to gauge the satisfaction of penile implants in patients with PD. Analysis of this data supports patient counseling on weight loss prior to undergoing penile implant in order to improve patient satisfaction with appearance. Interestingly, difficult dilation intraoperatively was associated with less perceived pain by the patient postoperatively. Significance of this is unclear, but postoperative pain might be less among patients with corporal fibrosis due to prior injection therapy. This merits further investigation along with a larger patient population to determine if other factors such as racial differences may play a role in patient perceived satisfaction after penile implant placement in men with PD.
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