In this communication, we experimentally report, for the first time, that the MnO nanoclusters with cluster diameters of 5-10 nm show a ferromagnetic behavior with a phase transition from ferromagnetic to paramagnetic phases at 27 K even though their bulk phase is antiferromagnetic. We observed large coercivities up to 9500 Oe and a large remanence of 1.72 emu/g at 2 K, which are typically observed values for ferromagnetic materials. Although it is not clear, this abnormal ferromagnetic behavior of MnO nanoclusters may arise from cluster size effects.

This study shows that SPLS is both safe and feasible in colorectal cancer, and that it has equivalent or better short-term outcomes than conventional laparoscopic surgery. Accordingly, the authors conclude that SPLS can be an alternative to conventional laparoscopic surgery for colorectal cancer.

The outcomes of SP TEP hernia repair for operation time and morbidities were comparable to CL TEP, and postoperative pain was lower at 7 days than in CL TEP hernia repair. The SP TEP technique can be recommended as an alternative treatment for inguinal hernia repair in experienced hands.

In our experience, SP-LHR via the colostomy site was safe and feasible, and may be considered an additional surgical option for experienced SPLS surgeons in selected patients.

As a central feature of neuroinflammation, microglial dysfunction has been increasingly considered a causative factor of neurodegeneration implicating an intertwined pathology with amyloidogenic proteins. Herein, we report the smallest synthetic molecule (N,N′-diacetyl-p-phenylenediamine [DAPPD]), simply composed of a benzene ring with 2 acetamide groups at the para position, known to date as a chemical reagent that is able to promote the phagocytic aptitude of microglia and subsequently ameliorate cognitive defects. Based on our mechanistic investigations in vitro and in vivo, 1) the capability of DAPPD to restore microglial phagocytosis is responsible for diminishing the accumulation of amyloid-β (Aβ) species and significantly improving cognitive function in the brains of 2 types of Alzheimer’s disease (AD) transgenic mice, and 2) the rectification of microglial function by DAPPD is a result of its ability to suppress the expression of NLRP3 inflammasome-associated proteins through its impact on the NF-κB pathway. Overall, our in vitro and in vivo investigations on efficacies and molecular-level mechanisms demonstrate the ability of DAPPD to regulate microglial function, suppress neuroinflammation, foster cerebral Aβ clearance, and attenuate cognitive deficits in AD transgenic mouse models. Discovery of such antineuroinflammatory compounds signifies the potential in discovering effective therapeutic molecules against AD-associated neurodegeneration.

Many approaches have been proposed for the treatment of bezoars, such as gastroscopic fragmentation, nasogastric lavage or suction, and enzymatic therapy. Because gastroscopic removal has not always been successful, especially in large gastric bezoars, surgical removal by gastrotomy through abdominal incision has been performed. With the advent of laparoscopic surgery, it became possible to remove such lesions without large abdominal incisions. In this case, we present a 62-year-old male who had gastric phytobezoar that was successfully treated with a laparoscopic technique.

BackgroundA hypoxic-preconditioned secretome from stem cells reportedly promotes the functional and regenerative capacity of the liver more effectively than a control secretome. However, the optimum oxygen partial pressure (pO2) in the cell culture system that maximizes the therapeutic potential of the secretome has not yet been determined.MethodsWe first determined the cellular alterations in adipose tissue-derived stem cells (ASCs) cultured under different pO2 (21%, 10%, 5%, and 1%). Subsequently, partially hepatectomized mice were injected with the secretome of ASCs cultured under different pO2, and then sera and liver specimens were obtained for analyses.ResultsOf all AML12 cells cultured under different pO2, the AML12 cells cultured under 1% pO2 showed the highest mRNA expression of proliferation-associated markers (IL-6, HGF, and VEGF). In the cell proliferation assay, the AML12 cells cultured with the secretome of 1% pO2 showed the highest cell proliferation, followed by the cells cultured with the secretome of 21%, 10%, and 5% pO2, in that order. When injected into the partially hepatectomized mice, the 1% pO2 secretome most significantly increased the number of Ki67-positive cells, reduced serum levels of proinflammatory mediators (IL-6 and TNF-α), and reduced serum levels of liver transaminases. In addition, analysis of the liver specimens indicated that injection with the 1% pO2 secretome maximized the expression of the intermediate molecules of the PIP3/Akt and IL-6/STAT3 signaling pathways, all of which are known to promote liver regeneration.ConclusionsThe data of this study suggest that the secretome of ASCs cultured under 1% pO2 has the highest liver reparative and regenerative potential of all the secretomes tested here.Electronic supplementary materialThe online version of this article (doi:10.1186/s13287-017-0635-x) contains supplementary material, which is available to authorized users.

High temperature finite-size effects in the magnetic properties of Ni nanowires J. Appl. Phys. 112, 073906 (2012) Equilibrium magnetic states in individual hemispherical permalloy caps Appl. Phys. Lett. 101, 132419 (2012) Magnetic properties of Sm0.1Ca0.9MnO3 nanoparticles J. Appl. Phys. 112, 063921 (2012) Positive exchange bias and upward magnetic relaxation in a Fe-film/CoO-nanoparticle hybrid systemWe report fabrication of the arrays of ferromagnetic FeCo and FeCr binary nanocluster wires ͑NCWs͒ by thermally decomposing the Fe͑CO) 5 /Co 2 (CO) 8 and Fe͑CO) 5 /Cr͑CO) 6 metal carbonyl vapors, respectively, with a resistive heater placed in the middle of a pair of permanent disc magnets. The NCWs are produced through the pileup of binary nanoclusters along the lines of magnetic flux, perpendicular to the substrates attached to a pair of permanent disc magnet surfaces. For both arrays of FeCo and FeCr binary NCWs, the diameter of individual NCWs ranges from 8 to 20 nm and the NCWs exist as bundles with their length up to 2-3 mm. We observed compositional dependence of structure.