The structure-function relationships of toxin-antitoxin (TA) systems from Mycobacterium tuberculosis have prompted the development of novel and effective antimicrobial agents that selectively target this organism. The artificial activation of toxins by peptide inhibitors can lead to the growth arrest and eventual death of bacterial cells. Optimizing candidate peptides by hydrocarbon α-helix stapling based on structural information from the VapBC TA system and in vitro systematic validation led to V26-SP-8, a VapC26 activator of M. tuberculosis. This compound exhibited highly enhanced activity and cell permeability owing to the stabilizing helical propensity of the peptide. These characteristics will increase its efficacy against multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. Similar approaches utilizing structural and biochemical information for new antibiotic targets opens a new era for developing TB therapies.
A new donor (D)–acceptor
(A) type naphthalene-based oxazepine-containing
fluorophore, OXN-1, is reported, which shows unusually
high stability in various environments. Its photophysical properties
and structural stabilities under harsh conditions are thoroughly examined.
The high stability of OXN-1 is explained by quantum chemical
calculations. Its exceptional bioimaging capabilities for cells with
low cytotoxicity are verified. In addition, its deep tissue imaging
ability with two-photon microscopy (TPM) is evaluated.
Arc spray method has been widely used as contact layer forming method for lead welding in metallized film capacitor. The materials used as contact layer are Zn and Zn-Sn alloy etc. Metallized film capacitor show the change of electrical properties, particularly, equivalent series resistance(E.S.R) and dissipation factor(tan 6 ) with spray conditions of spray air pressure, material feeding speed and applied voltage. In this study, morphology, size and temperature of sprayed particles were measured and their effects on electrical properties were investigated. The size of particles is about 5 0 p m to 8 0 p m and the shapes of many particles is irregular form. The uniform small particles sprayed at 4bar were deposited densely. therefore, the capacitors made of these particles had low equivalent series resistance and low dissipation factor. After withstand current test, the capacitors with contact layer of smaller particle size show the smaller change of capacitance and dissipation factor.
A new near‐infrared emitting liposomal nano‐formulation was developed, which has a dipolar dye in the core and demonstrated for human cancer cells' fluorescence imaging.
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