Ischaemic dysfunctional myocardium with reversible perfusion impairment tends to recover function earlier after revascularisation surgery than myocardium with a persistent decrease in perfusion.

Recent progress in the development of non-invasive imaging technologies continues to strengthen the role of molecular imaging in biological research. Small animal imaging with bioluminescence has been validated recently in a variety of research models and have been shown to provide continuous quantitative monitoring of the location(s), magnitude, and time-variation of gene delivery and/or expression. This article reviews the role of in vivo bioluminescence imaging technologies as they have been used in imaging gene delivery and gene expression for molecular imaging applications. The studies published to date demonstrate that bioluminescence imaging tools will help to understand human diseases through small animal models.

No abstract

A b w m -To calculate regional myocardial blood flow, ensemble ICA (independent component analysis) was evaluated.Myocardial blood flow was estimated from dynamic H,I5O PET, and perfusion score was computed from myocardial SPECT data in this study. I n ensemble ICA, posterior pdf was approximated by a rectified Gaussian distribution to incorporate non-negativity constraint, which is suitable t o dynamic images in nuclear medicine. Major cardiac components were separated successfully by the ensemble ICA method. Mean myocardial blood flow was 1.2k0.40 mllminlg in rest, 1.85*1.12 ml/min/g in stress state. Reproducibility of data analysis for blood flow values were highly correlated (~0 . 9 9 ) .The image contrast between left ventricle and myocardium was better than other method. Perfusion reserve was decreased in the stenosis region. Applied ensemble I C A method will be a feasible method to handle dynamic image sequence obtained by the nuclear medicine techniques.KevworJ : SPM. Spuriul normolizution, Slundurd SFM2 remplotc,.Kar-em-sfundurd templute.