SET is a multifunctional oncoprotein which is ubiquitously expressed in all kinds of cells. The SET protein participates in many cellular processes including cell cycle, cell migration, apoptosis, transcription, and DNA repair. Accumulating evidence demonstrates that the expression and activity of SET correlate with cancer occurrence, metastasis, and prognosis. Therefore, the SET protein is regarded as a potential target for cancer therapy and several inhibitors are being developed for clinical use. Herein, we comprehensively review the physiological and pathological functions of SET as well as its structure‐function relationship. Additionally, the regulatory mechanisms of SET at both transcriptional and posttranslational levels are also discussed.

Objective: Our purpose was to use the Beers criteria to determine potentially inappropriate medications in people 65 years of age and older who were hospitalized in the Nephrology and Endocrinology Department of The Second General Hospital in Ulaanbaatar, Mongolia from October to December in 2017. Methods: A total of 75 patients' medical records were selected who were aged ≥ 65 and diagnosed with kidney diseases. The patient's age, sex, serum creatinine, the number of potentially inappropriate medications prescribed were determined. Descriptive statistics, frequency analysis, and t-tests were used for normally distributed variables. The Mann-Whitney U test was used for variables with a non-normal distribution. Results: Most patients for whom data were creatine clearance data were available (36/41, 87%) were prescribed at least one potentially inappropriate medication, and the number prescribed of potentially inappropriate medications was moderately correlated with length of hospital stay (r= .326, p < .05). The frequency of potentially inappropriate medications prescribed in patients with CrCL <60 ml/min was significantly higher than in patients with CrCL level 60 -90 ml/min (29/31 vs. 7/10, X 2 (1) = 50.45, p < .001). A total of 195 potentially inappropriate medications were prescribed to 75 elderly patients diagnosed with renal disease, and these included antibiotics, anticonvulsants, proton pump inhibitors, and calcium channel blockers. Conclusion: Potentially inappropriate medications were frequently prescribed to hospitalized geriatric patients with kidney disease. Health care professionals in Mongolia need to collaborate to optimize pharmacotherapy based on renal function to avoid the complications of potentially inappropriate medications for geriatric patients with kidney disease.

The cover image, by Buuvee Bayarkhangai et al., is based on the Review A comprehensive and perspective view of oncoprotein SET in cancer, DOI: 10.1002/cam4.1526.