Hydrogenation of aqueous glucose solution was performed in batch and continuous reactors using supported nickel and ruthenium catalysts. Preparation methods were precipitation, impregnation, solgel and template syntheses, and SiO 2 , TiO 2 , Al 2 O 3 and carbon were used as support materials. A procedure for the one-step synthesis of templated metal on support catalysts was established. The influence of support material and preparation methods was studied and the results were compared with those of an industrial nickel catalyst. In a detailed study taking more than 1100 h time on stream we investigated the deactivation of the industrial catalyst and a supported ruthenium catalyst, and evaluated the deactivation mechanisms. As yet unpublished side products of the glucose hydrogenation were identified and a scheme of the reaction network was set up.
Global competition leads to a need for a fast time to market and increased resource efficiency. Continuous processing, module‐based plant design, and multipurpose equipment are recently discussed approaches for the fine‐chemical industry. As a representative, the downstream process of amino acid production is discussed herein. A conventional batch procedure was transferred to a continuous process and realized in a modular miniplant, which comprised of evaporation in a wiped‐film evaporator, seeded cooling crystallization in a coiled tubular crystallizer, and solid/liquid separation on a vacuum belt filter. The operations were realized on‐skid with individual automation systems and integrated sensors. L‐Alanine was successfully processed in steady‐state operation.
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