ng/mL (clinics A, B, and C) and 131 to 150 ng/mL (clinic D). Rivaroxaban's correlation between the anti-FXa assay and PT ranged from r50.91 to r50.73, but PT was still within normal limits when with rivaroxaban concentrations of 91 to 110 ng/mL (clinic A), 51 to 70 ng/mL (clinic B), and 171 to 190 ng/mL (clinic D). Overall, the slopes of the regression lines were relatively small, showing that the PTT and APTT were not particularly responsive to DOAC concentration. This observational study was limited by not using gold standard methods to assess DOAC concentrations and that the laboratories were spread across four different facilities, allowing for variability in reagents and coagulometers used.
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