Objective
To investigate the effect of continuous lung ventilation with low tidal
volume on oxidation parameters, such as thiol/disulphide homeostasis and
albumin-adjusted ischemia-modified albumin (AAIMA), during cardiopulmonary
bypass (CBP) in coronary artery bypass grafting (CABG).
Methods
Seventy-four patients who underwent elective CABG with CPB were included in
the study. Blood samples were taken in the preoperative period, 10 minutes
after CPB, and six and 24 hours postoperatively. Patients were assigned to
the continuous ventilation group (Group 1, n=37) and the non-ventilated
group (Group 2, n=37). The clinical characteristics, thiol/disulphide
homeostasis, ischemia-modified albumin (IMA), and AAIMA levels of the
patients were compared.
Results
A significant difference was found between the groups regarding native thiol,
total thiol, and IMA levels at the postoperative 24
th
hour
(
P
=0.030,
P
=0.031, and
P
=0.004, respectively). There was no difference between
the groups in terms of AAIMA. AAIMA levels returned to preoperative levels
in Groups 1 and 2, at the 6
th
and 24
th
postoperative
hours, respectively. Length of hospital stay was significantly shorter in
Group 1 (
P
<0.001) than in Group 2.
Conclusion
Continuous ventilation during CPB caused an increase in native and total
thiol levels, an earlier return of AAIMA levels, and shorter hospital stay.
Continuous ventilation may reduce the negative effects of CPB on myocardium
(Table 2, Figure 1, and Reference 31).
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