The transmembrane potential (TMP) of a cell exposed to harmonic or transient electric fields is the main parameter for a successful permeabilization of a cell. Obviously, TMP can be computed with a finite-element method, but the high contrast between sizes and electromagnetic properties of the cytoplasm, the membrane, and the extra-cellular medium leads sometimes to inaccurate numerical results.
Influences of membrane conductivity and frequency on the accuracy are studied. Optimization of transient waveforms is proposed for various shapes of cells.Index Terms-Bioelectric phenomena, biological cells, electromagnetic field computing, finite-element method (FEM).
International audienceComputation of electromagnetic fields in high resolution computational phantoms requires solving large linear systems. We present the application of Schwarz preconditioners with Krylov subspace methods for computing Extremely Low Frequency (ELF) induced fields in a phantom
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