Acetals are obtained in good yields by treatment of aldehydes and ketones with trialkyl orthoformate and the corresponding alcohol in the presence of 0.1 mol % Bi(OTf)3.4H2O. A simple procedure for the formation of acetals of diaryl ketones has also been developed. The conversion of carbonyl compounds to the corresponding 1,3-dioxolane using ethylene glycol is also catalyzed by Bi(OTf)3.4H2O (1 mol %). Two methods, both of which avoid the use of benzene, have been developed.
Protection
Protection O 0345A Simple and Versatile Method for the Synthesis of Acetals from Aldehydes and Ketones Using Bismuth Triflate. -Bismuth triflate is found to be a mild and versatile catalyst for the synthesis of a variety of acetals and 1,3-dioxolanes. Even acetals of diaryl ketones can be prepared in excellent yields. -(LEONARD, N. M.; OSWALD, M. C.; FREIBERG, D. A.; NATTIER, B. A.; SMITH, R. C.; MOHAN*, R. S.; J. Org.
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