The Visible and Infrared Survey Telescope for Astronomy (VISTA) is the 4-m wide-field survey telescope at ESO's Paranal Observatory, equipped with the world's largest near-infrared imaging camera (VISTA IR Camera, VIRCAM), with 1.65 degree diameter field of view, and 67 Mpixels giving 0.6 deg 2 active pixel area, operating at wavelengths 0.8−2.3 µm. We provide a short history of the project, and an overview of the technical details of the full system including the optical design, mirrors, telescope structure, IR camera, active optics, enclosure and software. The system includes several innovative design features such as the f /1 primary mirror, the dichroic cold-baffle camera design and the sophisticated wavefront sensing system delivering closed-loop 5-axis alignment of the secondary mirror. We conclude with a summary of the delivered performance, and a short overview of the six ESO public surveys in progress on VISTA.
Artemisinin and its derivatives are a promising new class of antimalarial agents containing an endoperoxide bridge. [14C]Artemisinin alkylated various proteins in vitro. Between 5 and 18% of added drug bound to hemoproteins such as catalase, cytochrome c, and hemoglobin. However, it did not react with heme-free globin. For catalase and hemoglobin, most of the drug reacted with the protein moiety rather than the heme. Artemisinin bound to human serum albumin (HSA) more efficiently at pH 8.6 than 7.4, more efficiently in Dulbecco's PBS than in Tris-HCl buffer, and better when HSA had been made fatty acid-free. Dihydroartemisinin also bound to HSA, whereas deoxyartemisinin, an inactive derivative, did not. There was no binding between DNA and artemisinin. These data provide insight into the mechanism of the reaction between artemisinin and proteins.
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