Osteoporosis is a disease of ascending character in the world population; in this context, bone biomarkers are being increasingly studied in order to aid in the diagnosis and monitoring of these patients. The main objective of this study was a literature review of articles whose main theme was the use of biomarkers for bone formation and degradation, and to evaluate their possible applicability in clinical practice. Literature review was performed through articles indexed and published in the last five years in the PubMed database. The findings of this study showed that most of the previously selected articles were published in the last two years, and the most cited markers were bone resorption, C-terminal collagen telopeptide (CTX), showing the highest correlation with the dynamics of bone, and the biomarker of bone formation, bone-specific alkaline phosphatase (BAP), which is increased in the event of fracture or may suggest another bone disease. There was an increase in published articles, associating different bone biomarkers and their clinical applicability, especially for treatment control. Our findings suggest that in recent years there has been significant increase in publications evaluating the use of bone turnover biomarkers for bone formation and resorption and their possible clinical applicability, especially in the monitoring of treatment. Still, we believe that further studies need to be conducted to confirm these findings, given the advantages that bone biomarkers can deliver in the clinical management of the disease.
Infection caused by hepatitis B virus (HBV) is an important public health problem and can progress with death from cirrhosis and liver cancer. In 2017 it has been 21 years since the universal vaccination against HBV has been introduced in Brazil. The objectives are to analyze the reports of hepatitis B virus infection in the Brazilian public health system between 2010 and 2015 and to calculate incidence and prevalence of the hepatitis B virus infection. The methods are observational, descriptive, and cross-sectional epidemiological study of reports of hepatitis B infection in children under 20 years of age in Brazil between 2010 and 2015. There were 4275 cases in Brazil. The prevalence was 6.49 cases/100,000 inhabitants. The age group with the highest number of notifications in Brazil was from 15 to 19 years old (68.58%). The incidence dropped significantly in 2015, and the occurrences were predominant in females. The Amazon region presented the highest number of occurrences, annual incidence, and prevalence. The form of transmission was ignored in almost half of the cases, and the most reported form of transmission in Brazil was the sexual transmission. The most common coinfection was with the hepatitis delta virus (1.87%). Chronic hepatitis was the most prevalent clinical form. The prevalence and incidence of hepatitis B virus in children under 20 years of age showed a marked and progressive decrease, which indicates the efficacy of the vaccine. The form of sexual infection in adolescents reinforces the need for policies aimed at the prevention of sexually transmitted infections.
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