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Thirty different test patches of various thin film materials were chronically implanted in the subdural space of cats to determine their suitability as components for proposed neuroprosthetic devices. In particular, materials employed by the microelectronics industry were screened, and reactions were found to be quite dependent on specific formulations or surface preparations of otherwise similar materials. A nonspecific but severe complication of pressure necrosis under thin films that spontaneously roll and curl in vivo was noted.