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In recent years, increasingly serious incidents of violence have been committed by young men predominantly in the United States and Canada who self-identify as incels (involuntary celibates). Although these attacks often specifically target women, the principal source of their animus, men as well as children have been among the casualties in the series of shootings and vehicular homicides that have occurred at universities, high schools, shopping malls, and on city streets. Although, the incel worldview is not obviously political, its core ethos entails the subjugation and repression of a group and its violence is designed to have far-reaching societal effects. Accordingly, incel violence arguably conforms to an emergent trend in terrorism with a more salient hate crime dimension that necessitates greater scrutiny and analysis-especially as it spreads to Europe and shows similarities to and has nascent connections with other terrorist movements.

The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of “mast cell activation syndrome” (MCAS) grown significantly. Two principal proposals for diagnostic criteria have emerged. One, originally published in 2012, is labeled by its authors as a “consensus” (re-termed here as “consensus-1”). Another sizable contingent of investigators and practitioners favor a different approach (originally published in 2011, newly termed here as “consensus-2”), resembling “consensus-1” in some respects but differing in others, leading to substantial differences between these proposals in the numbers of patients qualifying for diagnosis (and thus treatment). Overdiagnosis by “consensus-2” criteria has potential to be problematic, but underdiagnosis by “consensus-1” criteria seems the far larger problem given (1) increasing appreciation that MCAS is prevalent (up to 17% of the general population), and (2) most MCAS patients, regardless of illness duration prior to diagnosis, can eventually identify treatment yielding sustained improvement. We analyze these proposals (and others) and suggest that, until careful research provides more definitive answers, diagnosis by either proposal is valid, reasonable, and helpful.

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