Introduction: Urinary interleukin 18 is an established predictor of delayed graft function (DGF) in kidney recipients (KRs) with prolonged cold ischemia. The purposes of the current study were to evaluate the diagnostic value of uIL-18 as a predictor of: 1) DGF and 2) insufficient estimated filtration rate (eGFR Cockcroft-gault formula ) in a cohort of KRs with short ischemia time Methods: Thirty-nine KRs (KRs; male¼21; female¼18) were enrolled with short cold and warm ischemia (Clod ischemia<90 min & warm ischemia<10 min). DGF was defined as the requirement for dialysis within the first week. Sufficient and insufficient renal function at months 3, 6, 9 and 12 post-kidney transplantation (PKT) were defined as eGFR Cockcroft-gault > 60 mL/min/1.73 m 2 and #60 mL/min/1.73 m 2 , respectively. Urinary IL-18 and urinary creatinine (uCr) were measured at 2-, 12-, 24-, 48-, 60-and 72hrs PKT using the ELISA technique and the Jaffe method, respectively. Receiver operating characteristic (ROC) curve was generated for the prediction of DGF and insufficient eGFR by uIL-18. Optimum cut-off value was determined based on the Youden index. Results: The frequency of DGF and non-DGF were 15.4% and 84.6%. Comparison of gender, BMI, previous transplant, duration of dialysis, cause of ESRD, urine out-put, liquid intake, ischemia-reperfusion times, gender distribution and BUN between non-DGF and DGF groups revealed no differences. Neither absolute uIL-18 (pg/L) nor adjusted uIL-18 (pg/mg creatinine) at any time point offered good AUCs for the prediction of DGF. Frequencies of eGFR Cockcroft-gault #60 mL/min/1.73 m 2 at 3-, 6-, 9 and 12 months PKT were 20 (51%), 18(47.3%), 18 (47.3%) and 15(39.5%), respectively. At 3 months PKT, adjusted uIL-18 at 24-, 36-and 60hrs was significantly higher in the subgroup with insufficient eGFR than that with sufficient GFR. At 12 months PKT, the only difference was detected at 36hrs. ROC analysis revealed that adjusted uIL-18 at 36hrs PKT has AUC>0.80 for prediction of insufficient GFR at 12 months PKT. At 36hrs PKT, adjusted uIL-18 (cut-off: 60.6 pg/mg) predicted insufficient eGFR Cockcroft-gault at one year PKT with high sensitivity and specificity of 75% and 79.3%, respectively. Conclusions: Our results revealed that adjusted uIL-18 could not predict DGF. However, this marker forecasted insufficient eGFR Cockcroftgault at 1 st year PKT in recipients with short time ischemia. Owing to small sample size of the study, future and multicentre studies are deemed necessary to generalize these preliminary findings.
Purpose To evaluate the value of MRI T1 mapping with Gd-EOB-DTPA for assessing liver function. Methods Seventy-two patients who underwent Gd-EOB-DTPA-enhanced MRI for focal liver lesions at Beijing Friendship Hospital from August 2020 to March 2022 were prospectively enrolled, and variable-flip-angle T1 mapping was performed before and 20 min after enhancement. The Child–Pugh (C-P) score and albumin-bilirubin (ALBI) grade of liver function were assessed using the clinical data of the patients. Correlation analysis was used to evaluate the correlation between T1 mapping parameters and liver function grading and laboratory tests. Nonparametric tests were used to compare the differences among different liver function groups. The liver function classification efficiency of each image index was evaluated with receiver operating characteristic (ROC) curves. Results T1post was positively correlated with the C-P grade and the ALBI grade (r = 0.717 and r = 0.652). ΔT1 was negatively correlated with the C-P grade and the ALBI grade (r = -0.790 and r = -0.658). T1post and ΔT1 significantly differed among different liver function grades (p < 0.05). For the C-P grade, T1post and ΔT1 were significantly different between each pair of groups (p < 0.05), and ΔT1 had a better diagnostic efficiency than T1post. For the ALBI grade, ΔT1 and T1post were significantly different between the NLF and ALBI1 groups (p < 0.05), and ΔT1 had a better diagnostic efficacy than T1post. T1post significantly differed between the ALBI1 and ALBI2 + 3 groups (p < 0.05), while ΔT1 had a weak ability to differentiate between these two groups. Conclusion T1post and ΔT1 were strongly correlated with the two liver function grades and can be noninvasive imaging indexes for evaluating liver function.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.